Desynchronosis: Types, Main Mechanisms, Role in the Pathogenesis of Epilepsy and Other Diseases


Desynchronosis, also known as desynchronization or dyssynchrony, refers to a state of disrupted coordination or timing among biological rhythms. These rhythms are essential for maintaining various physiological processes in the body. When desynchronosis occurs, it can have significant effects on health, including its role in the pathogenesis of certain diseases such as epilepsy. In this article, we will explore the types of desynchronosis, its main mechanisms, and its potential impact on epilepsy and other diseases.

Understanding Desynchronosis

Types of Desynchronosis

  1. Circadian Rhythm Desynchronosis: This type involves a mismatch between the body’s internal circadian clock and external cues such as light and darkness. It often occurs due to travel across time zones, leading to jet lag.
  2. Social Jet Lag: This type of desynchronosis occurs when there is a discrepancy between an individual’s biological clock and their social schedule. For instance, staying up late on weekends and waking up later disrupts the natural circadian rhythm.
  3. Shift Work Desynchronosis: People working in night shifts or rotating shifts often experience desynchronosis as their biological clock struggles to adapt to irregular sleep-wake patterns.

Main Mechanisms of Desynchronosis

  1. Melatonin Disruption: Melatonin is a hormone that plays a crucial role in regulating the sleep-wake cycle. Changes in light exposure, as seen in circadian rhythm desynchronosis, can disrupt melatonin production and release, affecting sleep patterns.
  2. Suprachiasmatic Nucleus (SCN) Dysfunction: The SCN, located in the hypothalamus, serves as the body’s master clock. Desynchronosis can lead to SCN dysfunction, resulting in improper synchronization of various biological rhythms.
  3. Neurotransmitter Imbalances: Desynchronosis may cause imbalances in neurotransmitters like serotonin and dopamine, influencing mood, sleep, and other bodily functions.

Desynchronosis and Epilepsy

Desynchronosis has been studied in relation to epilepsy, and while the exact mechanisms are not fully understood, some evidence suggests a potential link:

  1. Seizure Triggers: Changes in sleep patterns and disruptions to circadian rhythms can act as triggers for seizures in some individuals with epilepsy.
  2. Neuronal Excitability: Desynchronosis may alter the excitability of neurons, making the brain more susceptible to epileptic discharges.
  3. Anti-Epileptic Drug Efficacy: The timing of anti-epileptic medication administration is critical in managing epilepsy. Desynchronosis can affect drug metabolism and influence treatment effectiveness.

Desynchronosis and Other Diseases

In addition to epilepsy, desynchronosis has been associated with various other health conditions:

  1. Cardiovascular Disorders: Disrupted circadian rhythms and irregular sleep patterns have been linked to an increased risk of cardiovascular diseases.
  2. Metabolic Disorders: Desynchronosis can impact metabolism, leading to conditions like obesity, diabetes, and metabolic syndrome.
  3. Mood Disorders: Sleep disturbances resulting from desynchronosis may contribute to mood disorders such as depression and anxiety.


Desynchronosis, characterized by disrupted coordination of biological rhythms, can have significant effects on health and well-being. From jet lag and shift work desynchronosis to its potential role in epilepsy and other diseases, understanding and managing desynchronosis are essential. Maintaining consistent sleep-wake patterns, exposure to natural light, and seeking medical advice when necessary can help mitigate the adverse effects of desynchronosis on overall health.

FAQs (Frequently Asked Questions)

Can desynchronosis lead to chronic health problems?

Yes, chronic desynchronosis, such as prolonged shift work or frequent jet lag, can contribute to various health problems over time.

Are there treatments available for desynchronosis?

Yes, certain behavioral interventions, light therapy, and medication can be used to address desynchronosis.

Can desynchronosis affect cognitive function?

Yes, desynchronosis may lead to cognitive impairment, memory issues, and reduced alertness.

Is desynchronosis only related to sleep disturbances?

No, desynchronosis can also affect hormonal regulation, metabolism, and mood.

How long does it take to recover from jet lag?

The recovery time from jet lag varies for each individual but usually takes a few days to a week for the body to fully adjust to the new time zone.


  1. Scientific Journals: Look for research articles in reputable scientific journals that focus on circadian rhythms, desynchronosis, epilepsy, and related topics. Journals like “Nature,” “Science,” and “Journal of Biological Rhythms” might have relevant articles.
  2. Medical Databases: Utilize databases like PubMed, MEDLINE, or Google Scholar to search for scholarly articles, reviews, and case studies related to desynchronosis and its implications on epilepsy and other diseases.
  3. Academic Books: Check academic books written by experts in the fields of neuroscience, sleep medicine, and chronobiology. These books can provide in-depth knowledge and insights into the topic.
  4. Health Organizations: Websites of reputable health organizations like the World Health Organization (WHO) or the National Institutes of Health (NIH) might have information on circadian rhythms, sleep disorders, and their connections to various diseases.
  5. Universities and Research Institutions: Visit the websites of universities and research institutions that specialize in neuroscience, sleep disorders, and chronobiology. They often publish research findings and studies related to these topics.

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