Best Drug & Alcohol Rehab Centers in Mississippi

Mississippi recorded 702 drug overdose deaths in 2023, a rate of 24 per 100,000 people. Opioids were involved in 76.5% of suspected overdose deaths, with fentanyl accounting for 64%. Fentanyl deaths rose from 220 in 2022 to 258 in 2023. Provisional 2024 data shows roughly a 10% decline.

Mississippi faces unique challenges: it is one of the states that has not expanded Medicaid under the ACA, limiting access for many residents. Treatment options are concentrated in a few metro areas, leaving rural communities underserved. But the state's MSDH MSUD program provides free medication-assisted treatment statewide.

Here is what Mississippi offers for addiction treatment:

• Free and state-funded rehabs: The MSDH MSUD program offers free MAT statewide. Community mental health centers provide sliding-scale services
• Inpatient and outpatient programs: from large residential campuses to MAT clinics and community-based treatment
• Jackson metro: highest concentration of providers
• North Mississippi: Oxford Treatment Center serves the region
• Gulf Coast: Singing River in Gulfport and New Season in Biloxi

In this guide, we have reviewed 10 top rehab centers across Mississippi, covering their treatment methods, costs, and who they serve best.

Addiction in Mississippi: Key Statistics

Mississippi recorded 702 drug overdose deaths in 2023 (24 per 100,000). Fentanyl was involved in 64% of deaths. Opioids were present in 76.5% of suspected overdoses. Provisional 2024 data shows a ~10% decrease.

Here are the key numbers:

• 702 overdose deaths in 2023
• 258 fentanyl-related deaths (up from 220 in 2022)
• 76.5% of suspected overdoses involved opioids
• ~10% decline in provisional 2024 data
• No Medicaid expansion (limits treatment access)
• Rural treatment gap remains significant
• MSDH MSUD program provides free statewide MAT

Top Rehab Centers in Mississippi

Oxford Treatment Center (Etta)

Oxford Treatment Center near Etta in north Mississippi offers a full continuum of care from medical detox through residential, PHP, IOP, and outpatient. Run by American Addiction Centers, they provide evidence-based therapies and MAT on a rural campus. They are one of the largest residential treatment facilities in the state.

• Etta (north Mississippi)
• Full continuum: detox, residential, PHP, IOP
• American Addiction Centers network
• Evidence-based with MAT
• Large rural campus

Best for: People needing a full continuum of residential care in north Mississippi

Pine Grove Behavioral Health (Hattiesburg)

Pine Grove in Hattiesburg is the largest psychiatric and addiction treatment center in Mississippi. Part of Forrest Health, they offer full-spectrum addiction treatment alongside psychiatric care, making them the state's primary dual diagnosis facility. They treat adults and adolescents.

• Hattiesburg (south Mississippi)
• Largest treatment center in the state
• Forrest Health system affiliation
• Dual diagnosis specialization
• Adults and adolescents

Best for: People with co-occurring mental health and addiction disorders

Defining Wellness Centers (Brandon)

Defining Wellness Centers in Brandon (near Jackson) provides residential treatment with a holistic approach. They offer individualized treatment plans in a smaller, more personal setting than larger institutional programs. Their location near the state capital makes them accessible to the Jackson metro population.

• Brandon (near Jackson)
• Residential treatment
• Holistic, individualized approach
• Smaller, personal setting
• Accepts most insurance

Best for: Jackson-area residents wanting personalized residential treatment

Mississippi Opioid Treatment Center (Ridgeland)

Mississippi Opioid Treatment Center in Ridgeland provides outpatient medication-assisted treatment with Suboxone, counseling, and behavioral therapy. They focus specifically on opioid use disorder and serve the Jackson metro. Their model combines medication management with structured therapy sessions.

• Ridgeland (Jackson metro)
• Opioid-specific MAT
• Suboxone, counseling, behavioral therapy
• Outpatient model
• Jackson metro focus

Best for: Jackson-area residents needing opioid-specific outpatient MAT

Singing River Behavioral Health (Gulfport)

Singing River in Gulfport serves Mississippi's Gulf Coast with behavioral health and addiction treatment services. As part of the Singing River Health System, they have hospital-grade medical resources for complex cases. They are the primary treatment provider for the Biloxi-Gulfport metro.

• Gulfport (Gulf Coast)
• Hospital-based treatment
• Behavioral health + addiction
• Complex medical case capability
• Primary Gulf Coast provider

Best for: Gulf Coast residents needing hospital-based addiction treatment

Region 8 Mental Health (Meridian)

Region 8 Mental Health in Meridian provides community-based substance use treatment for east-central Mississippi. As a state-funded community mental health center, they offer affordable outpatient services, counseling, and referrals. They serve a predominantly rural region with limited private treatment options.

• Meridian (east-central Mississippi)
• State-funded community center
• Outpatient counseling
• Sliding-scale fees
• Serves rural communities

Best for: East-central Mississippi residents needing affordable community-based treatment

New Season DeSoto (Southaven)

New Season Treatment Centers in Southaven (DeSoto County) provides medication-assisted treatment with methadone, buprenorphine, and Suboxone. Located in the Memphis metro area, they serve north Mississippi's opioid-affected communities. Their clinic model provides daily or regular MAT alongside counseling.

• Southaven (DeSoto County, Memphis metro)
• MAT: methadone, buprenorphine, Suboxone
• New Season Treatment Centers network
• Outpatient clinic model
• Serves north Mississippi

Best for: North Mississippi/Memphis metro residents needing outpatient MAT

Lifecore Health Group (Tupelo)

Lifecore in Tupelo provides outpatient behavioral health and substance use treatment for northeast Mississippi. They offer counseling, group therapy, and referral coordination. As a community provider, they fill a treatment gap in the Tupelo/northeast Mississippi corridor.

• Tupelo (northeast Mississippi)
• Outpatient treatment
• Behavioral health + substance use
• Community-based services
• Serves northeast MS corridor

Best for: Northeast Mississippi residents needing local outpatient treatment

MSDH MSUD Program (Statewide)

The Mississippi State Department of Health runs the Medications for Substance Use Disorder (MSUD) program, providing free medication-assisted treatment for opioid use disorder across the state. The program includes counseling, behavioral therapy, and medical supervision at no cost to participants. This is the state's primary safety net for opioid treatment.

• Statewide coverage
• Free MAT for opioid use disorder
• Counseling and behavioral therapy included
• Medical supervision
• No cost to participants

Best for: Anyone in Mississippi needing free opioid treatment regardless of location or insurance

Baptist Behavioral Health (Jackson)

Baptist Behavioral Health in Jackson is the capital's hospital-based treatment provider. Part of Baptist Health Systems, they offer psychiatric and addiction services with full hospital resources. They handle complex medical and psychiatric cases that standalone facilities cannot manage.

• Jackson (state capital)
• Hospital-based treatment
• Baptist Health Systems affiliation
• Psychiatric + addiction services
• Complex case capability

Best for: Jackson residents needing hospital-based care for complex addiction and psychiatric cases

Free Rehab Centers in Mississippi

Mississippi's limited Medicaid coverage makes free programs especially important. The MSDH MSUD program is the most significant free resource.

Free or Low-Cost Options:

• MSDH MSUD Program - Free statewide MAT for opioid use disorder
• Region 8 Mental Health - Sliding-scale community treatment in Meridian
• Community mental health centers - State-funded facilities across Mississippi
• Mississippi Medicaid - Covers treatment for eligible residents

How to qualify for free treatment in Mississippi:

• MSDH MSUD Program: Free MAT for opioid use disorder (no insurance required)
• 988 crisis line: Call or text 988 for immediate crisis support
• SAMHSA helpline: Call 1-800-662-4357 for free referrals, available 24/7

For a full guide, see our rehab costs and insurance guide.

Types of Rehab Programs in Mississippi

Inpatient Residential Treatment

Mississippi has a small number of residential options, concentrated in Oxford Treatment Center, Pine Grove, and Defining Wellness. These facilities serve the entire state.

• 24/7 medical and clinical support
• Typical stay: 28-90 days
• Mississippi facilities: Oxford Treatment Center, Pine Grove, Defining Wellness

Outpatient and MAT Programs

MAT clinics are the most widely available treatment in Mississippi. The MSDH MSUD program, New Season, and Mississippi Opioid Treatment Center provide MAT throughout the state.

• Regular medication management and counseling
• Mississippi facilities: MSDH MSUD, MS Opioid Treatment Center, New Season

Hospital-Based Treatment

Singing River (Gulfport) and Baptist (Jackson) provide hospital-grade addiction treatment for complex medical cases.

• Full medical resources
• Mississippi facilities: Singing River, Baptist Behavioral Health

Cost of Rehab in Mississippi

Mississippi has some of the lowest treatment costs in the country, reflecting the state's cost of living. Free options through MSDH are a critical resource.

Program Type	Typical Duration	Average Cost
Outpatient/MAT	Ongoing	$1,000 - $6,000
Intensive Outpatient (IOP)	8-12 weeks	$2,500 - $10,000
Inpatient Residential	28-90 days	$4,000 - $20,000
Medical Detox	5-10 days	$1,500 - $5,000
MSDH MSUD Program	Ongoing	Free

Payment options at Mississippi rehab centers:

• MSDH MSUD: Free MAT statewide (no insurance needed)
• Mississippi Medicaid: Covers treatment for eligible residents
• Private insurance: Most plans cover treatment under the ACA
• Community centers: Sliding-scale fees based on income
• Note: Mississippi has not expanded Medicaid, limiting eligibility

How to Choose the Right Rehab in Mississippi

Mississippi has fewer treatment options than many states, so knowing what is available matters. Here is how to navigate what exists:

• Budget: MSDH MSUD provides free MAT. Community mental health centers offer sliding-scale treatment. Medicaid covers services for eligible residents.
• Location: Jackson metro (Defining Wellness, MS Opioid Treatment, Baptist). Hattiesburg (Pine Grove). North MS (Oxford Treatment Center). Gulf Coast (Singing River). DeSoto County (New Season). Tupelo (Lifecore). Meridian (Region 8).
• Residential: Oxford Treatment Center and Pine Grove are the primary options. Defining Wellness offers a smaller alternative near Jackson.
• Opioid-specific: MS Opioid Treatment Center, New Season, and MSDH MSUD.
• Dual diagnosis: Pine Grove is the state's primary dual diagnosis facility.
• Rural access: MSDH MSUD program has statewide reach. Telehealth is expanding.
• Aftercare: Look for programs with relapse prevention planning and connections to support groups.