MAT Explained: Your Guide to Medication-Assisted Treatment
MAT Saves Lives. Here Is How It Works.
Medication-assisted treatment (MAT) uses FDA-approved medications alongside counseling and behavioral therapy. It is the gold standard for opioid use disorder treatment. MAT reduces opioid overdose deaths by 50%, according to the National Institute on Drug Abuse. If you or someone you know struggles with opioid or alcohol addiction, understanding MAT options is an important first step.
MAT by the Numbers
- Reduces opioid overdose deaths by 50%
- Increases treatment retention by 75%
- Decreases criminal activity among those in treatment
- Improves employment outcomes and social functioning
FDA-Approved Medications for Opioid Use Disorder
Buprenorphine (Suboxone, Sublocade)
A partial opioid agonist. It reduces cravings and withdrawal symptoms without producing a significant high. Available as a daily sublingual film or monthly injection. Prescribable by any DEA-licensed provider as of 2023.
Methadone
A full opioid agonist dispensed at certified clinics. It stabilizes brain chemistry and blocks the effects of other opioids. Requires daily visits initially, with take-home privileges earned over time.
Naltrexone (Vivitrol)
An opioid antagonist. It blocks opioid receptors entirely. Available as a daily pill or monthly injection. Requires complete detox before starting.
MAT for Alcohol Use Disorder
Three medications treat alcohol dependence:
- Naltrexone: Reduces the rewarding effects of alcohol
- Acamprosate (Campral): Stabilizes brain chemistry disrupted by chronic drinking
- Disulfiram (Antabuse): Creates unpleasant reactions when alcohol is consumed
“MAT is not replacing one addiction with another. These medications normalize brain chemistry, the same way insulin treats diabetes. Stigma against MAT costs lives.” – American Society of Addiction Medicine
Finding a MAT Provider
SAMHSA’s treatment locator (findtreatment.gov) lists MAT providers by location. Outpatient programs commonly offer MAT. Detox centers initiate MAT during the withdrawal phase for continuity of care.
Sources
This article was medically reviewed and draws from peer-reviewed research and clinical guidelines published by:
- National Institute on Drug Abuse (NIDA)
- Substance Abuse and Mental Health Services Administration (SAMHSA)
- Centers for Disease Control and Prevention (CDC)
- MedlinePlus — U.S. National Library of Medicine
Content is reviewed for medical accuracy by our editorial team. Last reviewed: March 16, 2026.
Medical Disclaimer: This article is for educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making changes to your treatment plan. If you are experiencing a medical emergency, call 911 immediately. For substance use support, call SAMHSA at 1-800-662-4357 (free, confidential, 24/7).